https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21994 Thu 28 Oct 2021 12:36:38 AEDT ]]> Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14218 Sat 24 Mar 2018 08:24:47 AEDT ]]> Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15982 -/- mice had reduced infection, inflammation, and mucus-secreting cell hyperplasia. Surprisingly, infection of wild-type (WT) mice did not increase IL-13 production but reduced IL-13Rα2 decoy receptor levels compared with sham-inoculated controls. Infection of WT but not Il13-/- mice induced persistent AHR. Infection and associated pathology were restored in infected Il13-/- mice by reconstitution with IL-13. Stat6-/- mice were also largely protected. Neutralization of IL-13 during infection prevented subsequent infection-induced severe AAD. Thus, early-life Chlamydia respiratory infection reduces IL-13Rα2 production, which may enhance the effects of constitutive IL-13 and promote more severe infection, persistent AHR, and AAD.]]> Sat 24 Mar 2018 08:23:40 AEDT ]]>